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A concentration this high is achieved at the peak of the Ca 2+ gradient in the granular layer of the epidermis (Elias et al., 2002 https://media.licdn.com/dms/image/v2/D4E22AQFsd-R9aGDF1Q/feedshare-shrink_800/B4EZ.FO0a3JgAc-/0/1784646682606?e=2147483647&v=beta&t=shua2BEoR6obpAqcE8-B0SfITXeh4zrswhwPo5mc9UM Skin tightening Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast | Nature Communications Nuanca:Grape

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