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Combining these compounds, plus an unvalidated NAD+ nasal spray format, constitutes an off-label stack that has not been studied for safety or efficacy in any clinical trial

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Moreover, berberine can also improve FAO and rescue mitochondrial function by inducing CPT1 and CPT2 in podocytes, which further attenuates lipid accumulation and ROS overproduction in DKD (Qin et al., 2020)