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CXC chemokines, including CXCL1, CXCL2, CXCL5, CXCL6, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL16, have been identified with abnormal expression levels in synovial fluids, synovial tissues, fibroblasts, and endothelial cells of RA patients ( CXC chemokines,like CXCL1, CXCL2, CXCL5, CXCL8, CXCR1, and CXCR2, generally, are involved in neutrophil chemotaxis ( Table 1 , inhibitors or antagonists of these targets have shown good results in animals, such as CXCR3, CXCR4, CXCL10, CXCL12, and CXCL13, especially the antibody of CXCL10 (MDX-1100) has entered clinical trials ( ( Figure 2 )