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Notably, reactive astrocytes closely interact with Aβ plaques and degrade Aβ plaques in an apolipoprotein E epsilon 4 (APOE) gene-dependent manner by releasing amyloid-degrading enzymes such as insulin-degrading enzyme (IDE) and matrix metalloproteinases (MMP-2, MMP-9) 48,49

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[PubMed] [Google Scholar] 48

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