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It is influenced by appetite signaling, insulin resistance, genetics, fat distribution, hormones, sleep quality, inflammation, medications, stress, muscle mass, thyroid function, aging, and the body’s natural tendency to defend weight

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Regarding γ-Glu-Cys production, the proteolytic removal of Gly from glutathione by peptidase is an unlikely mechanism because prior removal of the γ-glutamyl group is required before removing the Gly unit [5]