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While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

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However, the respective half-lives of the two compounds would need to be evaluated in the treatment population, and the idea that NAC may be protective against acetaminophen-induced autism is speculative

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