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(d) Library design strategy: predicted binders exceeding 86 amino acid residues were truncated by generating overlapping 86-residue windows that collectively cover all interface residues and selecting the truncation window with the most favourable predicted folding ΔG

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The shared pathway When a GHRH analog binds the GHRH receptor on pituitary somatotrophs, it triggers intracellular signaling (classically via cyclic AMP) that promotes the synthesis and pulsatile release of stored growth hormone