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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction ( Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol ( m value around – 250 mV at pH 7) is consistent with the observed reduction by GSH