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An oxidant/antioxidant imbalance characterized by oxidative stress and low GSH levels is involved in the pathogenesis of idiopathic pulmonary fibrosis, since data show marked GSH deficiency in the lower respiratory tract of those patients (127)

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Additionally, it also functions as a thiol buffer for various cellular proteins such as metallothioneins and thioredoxins, and as a key cofactor for numerous enzymes [3]