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Introduction of the mutation Q141K encoded by the common SNP (rs2231142) by site-directed mutagenesis resulted in 53% reduced urate transport rates compared to wild-type ABCG2 ( p A polymorphism located in exon 5 leads to the replacement of the glutamine residue with a positively charged lysine residue

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Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure