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First in human phase I study of BSI-201, a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in subjects with advanced solid tumors, 2008

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While in plants these proteins remain to be identified, in mammalian tissues it is considered that the anti-apoptotic factor Bcl-2 is a crucial component regulating GSH transport into the nucleus, as it is in mitochondria (Voehringer et al., 1998)