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This has led to an update to the Product Information for all metformin-containing medications

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System Xc − consists of SLC7A11/xCT (solute carrier family member 7 member 11) and SLC3A2 (solute carrier family 3 member 2), and is a transporter of glutamic and cystine that promote its transport on the plasma membrane (Aschner et al., 2022)