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72 A 2021 meta-analysis of 16 RCTs, involving 987 patients with SUDs, found a significant decrease in craving symptoms and a significant improvement in depressive and withdrawal symptoms with NAC compared with control, whilst lower smoking frequency failed to reach statistical significance

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Some research and reviews also explore central nervous system and gut–brain axis concepts, but this remains largely mechanistic and preclinical rather than a clear, proven human therapy

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