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Furthermore, curcumin also acted as early intervention to limit the accumulation of amyloid in vivo as it bound directly to small β- amyloid species, which in turn successfully hindered the aggregation and formation of fibril [248]

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Using an assay that employs a first step of antibody-based immunoenrichment followed by quantification of peptide isoforms using mass spectrometry, Wang et al (129) detected increased plasma levels of SDF-1α [1–67] and decreased levels of SDF-1α [3–67] in C57BL/6 mice acutely treated with the DPP4 inhibitor MK-0626