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As the GSH/GSSG ratio decreases in diabetes, exogenous administration of GSH appears to restore this ratio.43 It is presumably due to the availability of GSH to scavenge free radicals and reduce OS

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Likewise, fully maintained spatial learning and memory of the rats in the Morris water maze test was ascribed to hippocampal synaptic plasticity and NMDA receptor function [237] involving the entorhinal and perirhinal cortices, the prefrontal cortex, the cingulate cortex, the neostriatum, and perhaps even the cerebellum in a more limited way [237]