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For example, a ketogenic diet alleviates urate crystal-induced gouty flares by increasing BHB, which can block NLRP3/caspase-1-dependent IL-1β expression in neutrophils and urate crystal-activated macrophages, reducing inflammatory neutrophil recruitment [32]

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Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy, with its bioactive components preventing VEGF-induced retinal vascular hyperpermeability

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