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The FDA also categorizes which bulk drug substances compounders may use when creating custom medications, and in late 2023, the agency flagged 19 popular peptides — BPC-157, TB-500, and others — as Category 2 (an FDA designation for bulk drug substances that present significant safety concerns and may no longer be used in compounding), effectively banning them from traditional compounding

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Meanwhile, peptides like BPC-157, TB-500, CJC-1295, and ipamorelin have built diehard followings in the wellness world despite lacking US Food and Drug Administration (FDA) approval for any indication