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As well, an increased tumorigenic potential is associated with a heteroplasmic ND5 mutation that results in apoptosis resistance and increased activity of the PI3K/Akt pathway [38]

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On the other hand, our group has reported that central DA receptor blockade with metoclopramide was able to enhance the GH response to GHRH during periods of physiologically increased delivery of SS to the pituitary, but not when the SS tone appeared to be low [65]