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A few commenters suggested adding 10 or 15 performance add-on points for clinicians practicing in challenged economic areas, such as those with a high score in the area deprivation index while another commenter suggested providing bonus points or favorable benchmarks for ASM participants serving high-risk populations

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Pharmacodynamic results showed that at a dose of 5 mg/mL, the piperine nanoemulsion increased the activity of tyrosinase and melanogenesis by 32.77% and 34.90%, respectively, with no significant toxicity observed, indicating promising application prospects