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Firstly, observations in aged mice (20–24-months-old) reveal morphological changes in astrocytes and alterations in territorial domain that may result in reduced contacts between adjacent astrocytes, disconnecting them from the greater pan-glial network which is essential for many homeostatic functions (e.g., K + spatial buffering, metabolic and cholesterol supply to oligodendrocytes

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Factors such as your metabolism, genetic predisposition, lifestyle habits (like diet, exercise, and sleep), and individual response to B12 can all influence the timeline for experiencing improvements