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(2015)).59 Researchers have been able to demonstrate sinusoidal DNA deposition, neutrophil accumulation and CCR2+ monocyte recruitment to be key factors in the pathogenesis of propagating liver injury following APAP hepatotoxicity.60–62 Through the application of laser scanning confocal microscopy a number of the features of innate immune activation in APAP-induced acute liver injury have been demonstrated in a mouse model