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406,407,408 It was shown that CSE was upregulated in bone metastatic PC cells and in patients with advanced PC, and the high expression of CSE in patients was associated with poor survival

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Disruptions of the TrxR1 system, although not substantially impacting either the cellular redox balance or GSH pools, disrupts embryonic patterning, Nrf2 regulation, and other signaling-dependent processes [49]