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Glutamine (Gln) metabolism in macrophage polarization is mainly manifested as a composite regulatory axis of “TCA cycle anaplerosis-mitochondrial metabolism-epigenetic coupling.” Its role is usually not reflected by the output of a single effector molecule, but rather by the coordinated shaping of polarization-related transcriptional programs through metabolic flux and key intermediates, particularly α-KG (59)

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Vitamin E (100 IU): Recycles glutathione, ensuring prolonged antioxidant activity

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