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In a study analyzing maternal mid-gestation (MMG) plasma at 18 weeks of gestation and umbilical cord blood plasma samples at birth, children that developed ASD later in their development exhibited metabolomic dysregulation, which is an accumulation of methionine levels in ASD children, among other metabolites [173], pointing to folate metabolism imbalances potentially diverting flux away from the formation of the S-adenosyl methionine (SAM) cofactor, which is essential for the methylation reactions that underpin epigenetic regulations [41]

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Kurien BT, Scofield RH