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Lysine Catabolism via the Saccharopine Pathway There are several, at least three, pathways for lysine catabolism but the primary pathway utilized within the liver of humans is one that begins with the formation of an adduct between lysine and 2-oxoglutarate (α-ketoglutarate) called saccharopine

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Malnutrition is associated with conditions consistent with GSH depletion, which may support its role of placing patients at further risk for hepatotoxicity