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GPX4 was predominantly localised in the chloroplast, but also involved in ROS metabolism of nucleus and cytoplasm through interactions with GSTs

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The therapeutic use of polyphenols against cancer is based on their diverse range of biological activities, encompassing antioxidant effects, interactions with cellular receptors, apoptosis induction, modulation of cell signaling, alterations in cell cycle, regulation of cell proliferation, inhibition of angiogenesis, influence on inflammation and the immune system, epigenetic modifications, and modulation of gene expression [90]