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Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor-γ-coactivator-1a (PGC1α) pathway, possibly via the subsequent activation of Nrf2 [161]

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One approach, he said, involves packaging peptides inside nanoparticles, microscopic carriers designed to protect the drugs and help deliver them more effectively to their intended targets