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In rat HD models, neuropathological changes in the rat striatum were induced by 3-nitropropionic acid, and L-theanine exhibited neuroprotective effects, which mainly depended on not only inhibiting the production of harmful NO but also preventing the change of neurotransmitters in the striatum (51)

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Furthermore, a small study with GAD diagnosed patients showed reduced microbial richness among males and females (Jiang et al., 2018) while SAD patients maintained normal diversity (Butler et al., 2023)