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To be more specific, as one of the lipid antioxidants, GPX4 serves as both a guardian against oxidative damage as well as a key regulator of physiologically versatile signaling lipids, such as oxygenated PUFAs-derived arachidonic acid (AA) and its metabolites [100,135,149,150]

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doi: 10.1016/S1567-5769(03)00024-9