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It is largely the positive pre-clinical results from studies, usually in rodents, which drive progress for applicability in chronic human disease, but even these show considerable discrepancies in translation into patients

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Knezevic M., Gojkovic S., Krezic I., Zizek H., Vranes H., Malekinusic D., Vrdoljak B., Knezevic T., Horvat Pavlov K., Drmic D., et al