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Finally, glutathione deficiency is known to contribute to oxidative stress, and has an important role in aging, as well as in the pathogenesis of different diseases, such as neurodegenerative diseases, liver and kidney disorders, cystic fibrosis, diabetes, and cardiovascular illness

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Mitochondrial regulation is critical, as metabolic reprogramming driven by ectonucleotidase CD39 (ENTPD1) enhances mitochondrial biogenesis and oxidative phosphorylation to promote drug resistance [122] , while inhibition of the electron transport chain synergizes with ferroptosis induction, yielding potent antileukemic effects both in vitro and in vivo [123]