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The Sinclair lab was the first to identify a role for NAD+ biosynthesis in regulation of lifespan, that sirtuins activated by CR in mammals ( A Unified Theory of Caloric Restriction, 2005 ), the identification of small molecules that activate SIRT1 such as resveratrol, how organisms appear to have evolved to sense plant stress and declining food supply by having plant stress metabolites such as polyphenols activate longevity defenses ( The Xenohormesis Hypothesis, 2006 ), that relocalization of epigenetic factors such as SIRT1 in response to DNA breaks may be a cause of aging ( The RCM Hypothesis of Aging, 2008 ), how miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline ( The Mitochondrial Oasis Hypothesis, 2009 ), and the idea that epigenetic changes causing cells to lose their identify are a main cause of aging and this is a reversible process ( The Information Theory of Aging, 2019 )
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Maldonado, E., Urbina, F., & Solari, A
