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In cultured human aortic endothelial cells, ebselen attenuated hydrogen peroxide-mediated upregulation of pro-inflammatory pathways that are associated with atherogenesis, such as the activation of NFkB and JNK signaling and the increased expression of TNF-α and NOX2 [81]

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The neurologic complications of pernicious anemia, however, can persist even after B12 stores are fully replaced

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