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A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2)

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GPX4 metabolic mechanism As first reported in 1963 [82], lipid peroxidation generally refers to the process by which oxidants (such as free radicals) attack the unsaturated carbon bonds of lipids, especially those found in polyunsaturated fatty acids (PUFAs) [83]