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The activation of M2 Mφ is synchronized with the tilt of immune response to Th2, which is detrimental to the elimination of protozoa ( Plasmodium burden ( For helminths, the immunomodulatory strategies share many similarities with protozoa yet present quite diversities ( Heligmosomoides polygyrus bakeri ( Hpb ) and its products are found to affect the metabolism and effector functions of eosinophils, group 2 innate lymphoid cells (ILC2), Mφs and neutrophils, which play important roles in the early type 2 immune response against helminth infection ( Strongyloides venezuelensis ( Sv ) are protected from Nippostrongylus brasiliensis ( Nb ) infection for at least 3 months, and this protective effect may be related to the induction of long-term trained immunity programs in eosinophils and ILC2 (76)

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[DOI] [PubMed] [Google Scholar] 79.Nguyen T., Nioi P., Pickett C.B