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However, the causal mechanism by which benzene derivatives cause depigmentation has yet to be elucidated.100 Chemical leukoderma, however, does not share the autoimmunity changes (e.g., anti-TYRP1 antibody) as it occurs in vitiligo, despite promoting direct damage to melanocytes.101 Neural theory The neural theory of vitiligo is based on the clinical observation of lesion distribution: on dermatomes in the segmental type and symmetrical in nonsegmental vitiligo, alluding to the neuroimmunological influence in vitiligo