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In trying to understand the phenomenon the group of Lutz reported that an exoplasmic cross-linking of band 3 protein on human RBC not only enhanced binding of anti-band 3, but also that of purified 125 I-iodinated anti-spectrin NAbs 7–10 fold at 0°C in the presence of nearly physiological IgG and HSA concentrations (Hornig and Lutz, 2000)