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“The higher the dose, the less is absorbed.” At low or moderate doses, also called physiological doses, which are those we would get through food (although we could also include B12 provided by fortified foods or supplementation in very small amounts), absorption depends on the intrinsic factor secreted and the intestinal receptors of the Castle complex, which regulate absorption

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However, we are not concerned about the potential for unintentionally penalizing clinicians who adopt certain reporting pathways, as we believe our benchmarking methodology appropriately accounts for differences in measure specifications and data completeness across collection types