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Recommendation Use for 4–6 weeks Then take a 2–4 week break This break allows NNMT levels to rebound and resensitizes the body to the peptide’s metabolic signaling

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Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing Blood 2005;105:978-85, author reply 1137